The story of a paper

Together with my good friend and collaborator +Jacob Scott and our new collaborator +Artem Kaznatcheev , we have recently wrote (what I hope you will find) an interesting paper where we explored one of older games (emergence of motility in tumours mostly made of rapidly proliferating cells) and studied what happened when cells grow and reach an edge or a boundary. Normally I would try to recapitulate how did we do our work and what the results are but this time I do not need to bother since my collaborators are so much faster and better than me at this.

For a story of how this work started and how we did this work take a look at +Jacob Scott‘s latest post.

The work itself has been described in detail by +Artem Kaznatcheev on his own blog in the following post.


Writing grants

Unfortunately, a good deal of the work of a professional biomedical scientist in the US involves writing grants. It might provide a consolation to some to know that almost 100 years ago scientists still had to write grant proposals. I am not sure how many would have looked like this though:

Exploiting ecological principles to better understand cancer progression and treatment

I talked about this before in Google+ but the paper +Alexander Anderson and myself authored at the Royal Society Interface focus is now available for everybody to see. This is a somewhat unconventional type of paper as it is not exactly a research paper, a review paper or an opinion piece but a combination of all those. I must apologise that the article is not in an open access journal but the version in arXiv has all the content (even if it’s not as pretty as the journal version). Also, at least for some time, the article can be downloaded from Interface Focus [PDF].

By the way, the visuals of the article, including the following sketch by +Arturo Araujo describing the ecosystem of prostate cancer metastasis to bone, are quite impressive I think.

More on game theory and the evolution of invasive phenotypes

+Artem Kaznatcheev , a colleague at McGill University, has taken an old paper of ours and decided to do further analysis on it. The emergence of invasiveness is one of the hallmarks of cancer progression and space is likely to play a very important role. For that reason, I used both standard evolutionary game theory and cellular automata to see how much our original results would change if space is explicitly considered. The results can be found here. Now +Artem Kaznatcheev has worked on a Ohtsuki-Nowak transform so that we could still try to understand the role of space without sacrificing the analytical power of game theory. He blogged about it here and the preliminary results look promising. The number of neighbours a tumour cell has impacts the likelihood of motility to emerge in a tumour population. Hope we can learn more about this technique in the next few days now that +Artem Kaznatcheev is in Florida.

Back to blogger

I am back to blogger! Or to be more precise, we are. When I left blogger  a few years ago the idea was to start using a blogging platform that would allow me to share my ideas with likeminded people. That initially was Nature Networks, and eventually Google+. Now we are starting another experiment with blogger, one in which this blog will capture all the news and events related to the CancerEvo group at the Integrated Mathematical Oncology department at the H. Lee Moffitt Cancer Center in Tampa. Hope to see you all very often around these pages!

David and the CancerEvo group.