A nice math model that explains clinical data and is validated with a biological model. What’s not to like?
Ziv Frankenstein a postdoc at the department of Integrated Mathematical Oncology and a member of Sandy Anderson’s lab and the CancerEvo group. Together we have produced this model that shows how different microenvironments produce different selection pressures on the prostate cancer and thus yield different types of tumour cells. Bottom line? Gleason score is not the only thing you should look at if you are a urooncologist.
He will be giving an oral presentation tomorrow so if you are attending the AACR meeting on cellular heterogeneity (#aacrtme14) in the tumour microenvironment, do come.