Soil Amendments That Slow Cancer Growth

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This figure comes from a recent paper by Isacke and Barcellos-Hoff describing research by Alspach and colleagues. Their research confirms that many stromal cells that would normally hinder a tumour (for instance here) can actually help it in certain circumstances, for instance when tumour cells learn how to co-opt them or when the tumour grows in a tissue with senescent fibroblasts. It’s clear that tumour cells have to be able to co-opt and fool a lot of regular cells to succeed and although we need to know more about the genetic mutations that allow tumour cells to do that, it would be foolish to neglect the context in which these mutations emerge: the tumour ecosystem.